	   SnapGene      ¢GTTAGGCGTTTTGCGCTGCTTCGCGATGTACGGGCCAGATATACGCGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCTGGCTAACTAGAGAACCCACTGCTTACTGGCTTATCGAAATTAATACGACTCACTATAGGGAGACCCAAGCTGGCTAGCGTTTAAACTTAAGCTTGGTACCGAGCTCGAATTCGCCACCatggacgtgcaggcgcagaggccacctttgttggaagtgaagaggaacgtagaactgaaggcagccctggtgaagtcctcctcccgagtgcccctgtcagcaagcaggctcaagaggggtcctgaccagatggaggatgccttggagcctgcaaagaaacggacacgagtcatgggtgcagtgaccaaagttgacacatcccgtcccagaggaccactcctcagcacagtgtcacagacccagggccacactgcagctcagaaaggccctaagaagacaggacctcgtgggtgctctgctattggtacagtgctgaggagccagaagccagttcccgctgctcctgcccagaagcctggcacatccactgctcctgtggtggtagggaagagagctggcaaacgccctgcctgggacctgaagggccagttgtgtgacctcaatgaagagttgaaacgctatcgggagaagactcaaacgctggaactggagaaccggggtcttcgggagcaactcagagaggtccaggagcaggccacgaccctggggacagagcggaacaccctggaaggggagctggccagtgtacgcagccgagctgagcaggaccagcagaggctggagacgctgagtgcccgtgtcttggagctggaggaatgtctgggtaccagggaaaggctgcttcaggagcttcagggagagcggctgcaattgcaggaggagcggagcacactgagcacccagctggaggagcaggagaggaggtttcaggccacagaagcagctctgtcaagcagccaagaagaggtggtgtgtcttcggcagaagactgaagcccaggtgaccttactggctgagcaaggagaccggctctatgggttagagatggagcggcgacgactccacaaccagctgcaggaactgaagggcaatatccgggtgttctgccgcgtgcgccctgtcctcgaaggggaatccactccatctcctggcttcctcgtgtttcctcctggccctgctggaccctctgatcccccgacgggccttagcctctcacgatctgatgatcggcgctccaccctgactggggccccggcccccactgtccgccatgatttctcctttgatcgggtgttcccgccgggaagcaagcaggaggaagtgtttgaggagatcgccatgcttgtccagtcagcactggatggctaccctgtgtgcatttttgcctatggacagacaggcagtggcaagaccttcactatggaaggagggcctaggggagacccccaattggaagggctgatccctcgggccatgcggcatctgttctctgtggcccaggagatgagcggccagggctggacatacagttttgtggcgagttacgtagagatctacaatgagaccgttcgagacctgctagctactgggccccgcaagggacaagggggcgagtgtgagatccgtcgggcaagcccaggaagtgaggagcttactgtcaccaatgcccgctatgtccctgtttcctgtgagaaagaggtggaggccctgctccatttggctcatcagaaccgggctgtggcccacactgcccaaaataagagatcatcacgcagtcatagtgtgttccagctgcagatttctggagagcatgcagctcggggcctgcagtgtggcgctccgctcaaccttgtggacctagctgggagtgagcggctagaccctggcttacacctaggccctggggagcgtgatcgtcttcgggagacacaggccattaacagcagtctgtctacactgggactggtcataatggccctgagcaataaggagtcccacgtgccttaccgaaacagcaagctcacctacttgctgcagaactctctgggtggcagtgccaagatgcttatgtttgtgaatatttctcctctggaagagaatgtctccgagtctctgaattcactacgctttgcttccaaggtgaaccagtgtgtcattggtactgctcaggctaataagaagGGATCCGACTACAAAGACCATGACGGTGATTATAAAGATCATGACATCGACTACAAGGATGACGATGACAAGTAGTGAGGGCCCGATATCTCGACAATCAACCTCTGGATTACAAAATTTGTGAAAGATTGACTGGTATTCTTAACTATGTTGCTCCTTTTACGCTATGTGGATACGCTGCTTTAATGCCTTTGTATCATGCTATTGCTTCCCGTATGGCTTTCATTTTCTCCTCCTTGTATAAATCCTGGTTGCTGTCTCTTTATGAGGAGTTGTGGCCCGTTGTCAGGCAACGTGGCGTGGTGTGCACTGTGTTTGCTGACGCAACCCCCACTGGTTGGGGCATTGCCACCACCTGTCAGCTCCTTTCCGGGACTTTCGCTTTCCCCCTCCCTATTGCCACGGCGGAACTCATCGCCGCCTGCCTTGCCCGCTGCTGGACAGGGGCTCGGCTGTTGGGCACTGACAATTCCGTGGTGTTGTCGGGGAAGCTGACGTCCTTTCCATGGCTGCTCGCCTGTGTTGCCACCTGGATTCTGCGCGGGACGTCCTTCTGCTACGTCCCTTCGGCCCTCAATCCAGCGGACCTTCCTTCCCGCGGCCTGCTGCCGGCTCTGCGGCCTCTTCCGCGTCTTCGCCTTCGCCCTCAGACGAGTCGGATCTCCCTTTGGGCCGCCTCCCCGCCTGGAAACGGGGGAGGCTAACTGAAACACGGAAGGAGACAATACCGGAAGGAACCCGCGCTATGACGGCAATAAAAAGACAGAATAAAACGCACGGGTGTTGGGTCGTTTGTTCATAAACGCGGGGTTCGGTCCCAGGGCTGGCACTCTGTCGATACCCCACCGAGACCCCATTGGGGCCAATACGCCCGCGTTTCTTCCTTTTCCCCACCCCACCCCCCAAGTTCGGGTGAAGGCCCAGGGCTCGCAGCCAACGTCGGGGCGGCAGGCCCTGCCATAGCAGATCTGCGCAGCTGGGGCTCTAGGGGGTATCCCCACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGCATCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGGGGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAGCTAGAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCAATGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGGACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCGACGGATCGGGAGATCTCCCGATCCCCTATGGTCGACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGCTGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAATTGCATGAAGAATCTGCTTAGG  EE   %   .      +   4   ,   !      &            (   #   ;   3   '   #      -   5                     (   !         )   )      )                  !         &      !         &         %   :   &         ?       ,   ;      .   $   ;   &   -      /   "   !         #             "   0   +      '   "      %   "   3         "                        #                                        !   "                               )                        %   1   $   5   !         +   )      !   $      "   1   -                                                    $         "               "      -   ,   $      #   /   "            "   "   "      +          #   !   #   (   )   *         *                                 /   6   2   $   "   /   $   !   $               #               ?   ,   '   :                      +   %      -   #   1            7   3      #   (   9      (      &   3   *   4        % Y áfã-¼1ï™šo	Â	,”½�Žÿ3†«´µY2ƒ+î+¯Í:¼p¬¾. á xâ b¶s�Âì.‘ª½ið’›	Ã	Õ	ú	Ø
L¾÷�*3Ì
#’°;½º•eo<ð Z ÷ g ä‰_œ\Q
ãê g¶ßg™†1�,Îq„¿+  ÈNå™‘2è>‡›¯	p	'-•¢v4t‡¬Z¬L„à,ïÈ~PiÅ­D4 t û c·v‚/ÃÛí/_w}¡«¿ÂÇÝàæëPju„åñ/Âø_	œ	Ä	Ö	
å�¦Õ£¯Í5½<fñL, tÕ)€’ˆ¾jxáÿº~
o¿‡¢²¶ýuŒÔÁW…·Èís»ð�Áž%=M! Îãy¢Ù
Cƒìj+4âôú1½Ö'jž±¾ yP–±p½—ë â y!õ“Å
�PïÁC“‘	û	M�ø ë¼ßŠ–$“UÄ& ø ¬_7¡l:�]õR
®
ñ
´ähàåš‡Ï2¨T‚ÏDê“©#J& Œ MRÛ"oŠÁ
_·âŽ£Ý3MrˆÏü] ´Õî`Ò(èh ÀC!Œ-zè-D«&r§æ…À [ fhåü 
ëÈyyðr�ùÖ´O(  ÉOVþo Sœ}	lˆÎÜ…á o":‡¾ÁnAQ‡ GfÃ�‚Nd®E# ]‡º.X'’ÊÐ°U
ù.£Ç‹[}¤ìMÂ-eBì)x; œ }˜Ä][—²FWÑ¦?
		¥	°	Ì
²–›Ô;“u­@˜à[¦¸:B]vÊÓar…ð}¢Éš�·jŸb}3   “ Tæûš5õæ39é)9ˆû	q	¼	ß		
(í0Cw5n�­;x~²)×^y/Ýèú¬vÆÑ' ddwÃ-úY~ÀÞéìv‚æÀóù%ã‘v|¡¤°ø8À%?B†gM# †¸xÄÜø`¬çQe…ò0`lv¥í4	`	×	‚
§(î6PY=£�?Íò u ü H™²hVŸ�	
Ž
æeÖ¾ÙBœ÷ï…)UV- táƒ0zî0FKx¢®ÃÈÑáJk5Ãb	¡	Å	
NŽÎ­±æ¸h²ÝŠÕ%‚Ê“a5 +:6Qu–¯Æ*ü+2Ž¹kyâ »
Õ
À£³k¨ð™#Âãµ¸t¼¤ÁàYÒÂÑÇ&w‘  Ž÷·“ï,
Sˆ›�ÕR X4vŽÉJñH†Ÿ±N®Ô ç�¿o
„
–
Öhv°KÄ†*¶A>V£” ˆ&ÖÞ ‰	H
±
p·þ´þÍî‚‡  ¯szg£2`
�õfe¾×=ŸÙ  % Ï-„¹¬¿_¡W`‡q˜ 7 äLX	ô
DWín”!,5Skñ[az=—¥¦( øX‡b§6	Ë	Ú
ý
kžãèû2€ÑÚ(¢²Q\d²¾'|Ž¼¾Ïóìôü! ¹ Å î AJûEöbr î
ÆùbÄ½Ï½ÝùàE”"5wâè 1 ”³ÂÆD”Ù	5�©©ÒðV—QRÅþH† > ã zÚ"«É.u-ü	ß
	[Nì_Hs%kVWG"
)   « pºn©Æß‘¦Q=SðÕônx’	ª	è
!*÷…›Ÿ•3‹Í9=\�!‘Q‚) ù Ì`jmÎ'Qö	{	�	S
�ëÿ²ãæªésŠÒ3ÑUw…+EÁ§ª$ÔH ­8§¤;£¾ëŸ	É	m
¯
ò
#Qiõ›Ÿ1ªŒÛÓ ') #Y×¢:pžÚ^|¯¡H	J	y	·
¹
µàåáz|ˆÐoƒŠÂëRKØFEG ùJ¢(jª±"
Y
	t©ó&ÙÐ	”}›’çÙ[ S#p] É§œÚí�ýTX M � Õ N2qÄ¤ó4NsñÊÜ È þ %•`š®Ç¸«óÔVãBRK�Þ‰ÉÐç^H§4  3j‹¾[Ü#<‹Â
·+! . °Ÿ´nÓèò)Ÿ·âçÒüŸ{(ò ù@þ03˜ÀÎWÊSI   C ~ aXéD‚é”¬ç�‡¨Úç†+  µÖËïÜ~Läi
ïDÁÿ‹Õ.ƒE	i'/Õ%Y& c w Ì = ` rL	óc9i¡ÞóD"q�ä.À}‹æôž5s¥ÕÁ /¬ºgìƒÎ.Y
zñOVåP! \ ¼ ñ D›þR›Ù™ÌB	
»
õ>J~Äz–ÿ:z>žMÃ7g ígær…!Ï	í	ñ	ˆ
�
ÙOÉN=sú,óŒ =i½ý³C”Þ
Éü	Ø‘Ù¤2¨D×µ& ²ÓP°Åm7£	mõ.Aý‰ÌÚÝÈmpˆ¿!­8B…Œ¡‘!¥L•  pT�f!ž¯#;Â2CˆH„%�ƒO¯F_  , | ÊWÉ¨Ç	MBóâ�oðIþg¿e%  ÿ¬!~	ó½£ÂÏØî~†Æëõù«õ6Rs�Ä(ÖCÌ)zÆ]: ˆ»qû/Z¤ï@MV¼ãÿ(…rË?	U	h	v	ê	E
V
zŒ›¥ð¡¥éís€¹Ãí.öÜÅfi7:EÎÕí„& HV‰€ð¶L“nÑŽ±
2
úÈ¯È÷¿hõ×â3‚¯Ü+�*4cy ^³d	/Ñ\´¸ü v¨èûû »"'Cõûz&� ÒYÊÓ�¤ß~N³ðéÈ?  � Á*C|Ò2H\ez˜³ÚG‚ì@	R	˜	B
‰Ö‰ŒœÃÕ5¨P\^wÔðbs~²Ê›º€p‚×ÿ%ÝÇS  ¡~Å¼§}�Ù¦	Í
|¡”¿û�;CË†�£dß–¸	<n,  ‘™×›¤Ò�Å±	c
¡
¦
Œ§³UAv§¹Ð-|DbºÑÛ€ßj\™ÆkcA~š; vã^òFdX#		k	€	…	6
Ç
qB—Ø<v®O™áÆaõGñë›÷Tdu•8wƒÑøØ z˜ Rm¬Z”: C¥fy8x=y*il(MÅûH_zèj—´û–¾ÇÒ1#. ! Ú .íç29›	6öG‹:à	[
4gå6}•4®Ø÷Q0Þé_lãº6
|Û0$ ˜ Y}…T‹»êr	$
”|€Ü1DU{ƒ<‚ˆ³@ 
mÉÒ¬*­Cè; j ” ¤ ² 7Ue=2LüL†l5®ç4:*‰µÕü 	)	½	

)î…[>o�Ä
´È*3?ITˆ«�HÇþw`& à µeär˜,�©�»çî=‘˜×
&“s³f˜)…‚í»”hÄ;Cƒ½- xÄ	.O ¾ÁßåêO‡twƒä.¹Á
ä¥µ¢óù»0Õ&•ÇìTxÃO°¼$ eûí9ô­
Î yCÜï‡N/  Uý-\úZ–ôÉú»	Þ	Ë
ø’mŽ—£ßëw}¥±·9Á
@ŸÜçùe�A�(w|" s…cÂwy±÷ùX­èd_ò3	a	�
uí7å·g>A�›ö! ‡%�ö5PÅÝû*î	G
ƒ
Ô
Õ§ï˜QµÌÀGXÐÆ@†­“ $ rf†1a¦5	W	_
ü
V�Z^<[¤½V¥Îó ¹ÞÈa-RÅÔómw©	Ø	ç
a¨Ñ)¼ïUšQ�# "I¦Ö'9i{Í ½G	x	ž	X
¶
"s©èž%ÁÚ¦~|Ó×E‘ØZ L Ô ý 2iŠ½ªò›UÈæðÉ*3W  B b v ¯<ž³KWçb�C¿'å�æøÔ?$†ÍVÔ* šì<š˜A	ì	
�
f×�ÃØ	=Cò6" ÒÈ¯Äl6¢	Æ	Ë×ò}Å�®œø Bª‹¾ƒ $Ë¤”0 pUYÑïLUÉÒâþKmqœc	é	
1
š ³Çèû²çôúºÖá&h~69®ïƒúyb+ uÀÖâñ{1Gy£Ù�€ÄQ	j	—	5
AÂ§NO�ÅÏï¹ÞciÞ”vþÿl«m i 1„18SB4
´|Äú³Èkâ¹½/' ,ù—+•N�ºã�—
¬
Ö
¤´l(xžÛæøÂN“¯Ã€»':Bv{" bŒv°Ç,Óñ2	^
€
Ó
æ
û
UÐì™ä¶Ë]PõWZ’ !1ë;®z¼a�©×ñš$TÀ<¥ÓåÒÈÌ5�×% o¿ÕX7Rý
3lp³4
ÁÖM²úÄœÃAó¹Çu½ýá5£x.l" ‹­ø”ðå
ú
TÏŽ±ÖùÃSwò¿Æ�ÊÚå÷\ôM®ä¢�9Ö3 *-	JÍÎÚ‹Œ�GHI[\ÁÂYÙäõö./òóIJKL‡¬­ÌÍŸ ¡Ž ²,678¯°Õe � P+J¡.	KËTJ]Z5î�0ÇÎÚ-O±¹f 	Ï�‚¸Î-
‰œÛùŽø¡6Kˆó´¡³ µ" � Â ô GQÅ,K¬‚iÒ
…
‘Kw±j[Å6å?Ö'ÎÏ„.P¤ I ¿ Ý ¦•/	
p
Ð
¬Ê×9åLï÷¦±!Bjt?Wn²º S ¢è¸û—
L¬^im¿c�¡ìÈúùg‰ O À8ÌUY‡s+·1Ûß• ¨ ×  �ƒ¹ÏüŠÜú€c3Âƒ-y¢ 4!æ	.
�ÿXR¢«Îu!¶s … 
7�Ð'×òŠI
hq—�ù$9µÿÐ7â6±‰ôZÞˆ´ï ‰ß}	‰	²
<¸	ÊLïLHµ1Þ# r ‘ õ RvªÆLótž]h¤¿ß
°ÒžY_¿8R\Ææw`äê  Ã Hn­J3jì
áÂLöF²Ø7t ×(¡Ðí…Œ‘�  Ê -ƒÜg
†
lx@LÑ‹–ÚQ¥ ,c°{ŽÓf	a
’Ÿ­¶õþqgfk>¸Ï	J/! J g Ò Þ Ð³E	˜ºæšø}="C�»( ƒ À m0	

Ñ
ø
ÉËØ÷&ãð½ÀZX²÷r@³ & n p *k–q
.ÖM­éëo� ( §G…­:xT®§`¢aˆkuX^™ 4 ; ¶ ë >øB¹ü¾
X¤1d0@	¯Ù‘íMû9›t‰Š 8 F T _ `—¤£ã	õ
EÓ•jÀé${>¦É÷q  åMµ	Y	s
M¹o"-6T_dmÜ\Ë˜0§|Ÿ©Ìh é˜
b­înM“>‘lòb"¢hú: ž�¿YˆÌ	vV±üZÎ¥ªpåýˆ,2:\E½í! P 'Â	7	:	þ
9œé\ÒêO’Tý<It‘¸)©Ü«}Ý˜€" �Êc0lŸºä3=Û)³DàÒRe³à(r¿ôýõ6– ¸]˜Áù	¨Û
Íº^.ØX�£—¯/]¿9äî�Ðý  W Š Kß]‘ï
j‹ Åá{¾Þ à©µncmKé © ©—sc¾ÛáW°#U„^z º Æ ï B“ü÷![ 
ýÇú�7¥ÐÜúµŽ.£ã  * Ø 5F„ºÐ>c=	Ÿ
z‡Ýû<ÀìdzF•4Ã6ÕAx–P ÔÜ%ùÃÇIÜ	ç	/
‘ÓñS³Rv™Æÿ?" 5{g•ã
6Hªª YPWì 	Ÿ©,·qt‡ 2 � l�À¶[E£˜¬çÏŠ›Ê •´ê"Ì$	µ	Ú	õ	žþ§S»I) Ž•(ìaØÎ/C‹.@Ÿ„É&	÷	ý	Ä
\%¦˜úI¶ tûhboò#ð ? ‚°Üœ
à

i`W7²½[ † ä {ƒ#Ñ>
O �ÑXõß‰ Û8¬ÊÊóvÅJ
rí%:¹&8ãl™ŠHà-µãZ` ¡ ÞàTo	)
¯%øœŒÎ:gVð�"ŠœRwÄƒ §ðoªÇR�~Ï³
é
7Ë–™>bo¶2
 q
’§>ÖyŠ	“	·	:
=:è"€ B‰M]¤ê¹Þ ¬ óŠ»à$Õñ(ªõ«	¹ +UZ†
4¦ËM‘I’ßë% ö wÇMaŸŽˆ^0†š	Á	ù	P
+¡ué2ª«10K€Ç*}ÌO1 s ú Íôu�ÔÚ(^v|Üiî¡ÀàþB÷^	�	}
B‚Žë†Ôêüt‹Ó®4ÀÞVi�¼r€�K$ «Ú6!knÿ	À
^Ñ'³äçŸBSç,xq¨Îû%œøÕI\å%5 ’ › S\†¹|—ÃW~4EÐå¥Ï(R			|	¯	
T
±ì ÓZÒÖ`9]x†¡½mFÂd«uaÐë! ,JgÐI�4k¤¿ì 	
$âM� ÷ØÜÔA¢î(>Ì’U *9•®¶1�n
•
°
Ršj¯³´u�)£ßÑUv¢� 6 ®÷KWÊ	ó
“œ¸ RçedÙ«¡c†�ò+ 0 = Ÿ ¸ Ä í @IoÙúDm¨²¥<,í
Z¨ÅÃöÎ^G2Ì8j!výF!á�) i¡£®°&P¢ê	I	z	Ž	l
¸
P€êßâry{‰Ñòv„*‰‹ÒšDF  $Z;™ÆÈÓAQÃÙìŒSGÛ¦! Ë ŸÛ_}ãK	h
mž¶áæòòpÔ‚“Š.ý2—ÙÉRH$ .QØq„ ²B“ËÝð	‡
º
Øô=¹}y•£þ9Í1M§+LÂ‹  ±«ò@¢êlïôHr„€'Õ(K\" úˆ£îµ»„²T	g	u	D

®·öÿr¾¸guÛ!
2�ÛœôèŒ1  �)Ecšë�| 	A
b
¥
Æ
p‹ ¦Õ‹×4u`ôFC±Ú¹Ð•Ü
~;Y“9@™- -dK|KŠk¤ºÔ(	#
Z
“3f„ä7”‡hª'LŒ?GPÑý•B 5	_0Ú"  ß T´qíº	²e—„¶ÛîŽ¼� „$c^¨	»f¿¼U¬ A K a Ó ™F	!r¨çÂ
�&>#D)Y h ÑÇ	–	™Ê›ùb~}þª‚ nÔ 1	
Ò
Õ'O’ËA-k Ž OÎù
ÊÌÙøSFñ¾Åô[ÆËÙãò³�´ H N Á ¥
Ï
�älbärÕë&¥ù øs „ Ö 3€å	g–Wb#8áÁ5t°YÝ q É +bu\¾ÞÛf
k~¯àÁ¬ôpEsŠì_éI ' o jl²÷
È%ÕâSYèê : E ÿ =–£r
a£c?l’=®ØLÊ/öpsˆž¨  &œ¾—/›¹×ÍWN‘äCH–�®ß.9[Ñ¨ªãÜ5  ) V ‰ 4’\¨=Zž
y†;ëzyß¯¨´@m]bl € kŒ¿$Hf´	ô	â
Gýë˜º>‰šp ‚”BƒÈ=
Ã
¸,Y_ ¦ÝŒ©(
®ˆ¥Uaœ£én‰vÃ$ …¸Ù€ uý	¿
* tè1Ó0A­/ ¼|lNÍú›÷[ÏœJ / 5 < · ì ?ØùC±µV€Y’Í
~@¢bËTu¡€ 
 ’O�	k
O˜Åéó¸ññÒ”ýÌÓ)0’-ü1™ÁŠC" 
 º¹@
¤
o¥Ô2eƒã½éEF°ÚîóG1Aÿ'4:X^‹  ` ˜bdq–ƒÁ	|©«œ G ¤ÍÓä	f�ÔãEVakê%‘ÅÊØøŒ,j 9 D at›e
ö
ß$ko×áG•­-Z§©âÛèr~‡ U  ˆ ¥“AYÇ³	'
FxêyÞê›è?mˆ Â" 	 ·×	U¸N	j
£
N—sðÌ/¬¼“/FÌ,0aš&Z  ÌwŽÞcpxâ#U`jnÝÖÄ×¨á‹}ªi-  ¶¶·MvºMÂÃ.efghi©ª«»Ý‘’dŒ
()*+h™ÃÖ hi, æ }æ%ðÝNåZ	t
µ»GQWÍEN!.CÄ7Þ e]�„j¯Èi1jÍ$  êé$sÒ	RRXd:Å8ß?’ó/^‚Ä~·çõí2±©Ö d �¦ñÙ™
¶ô¢m¶6ei÷k# ¡O![	u
c¼ï F"/ßoN#ŽfpÁ#°ÉŸjû;¦/ x Í ç ~ç&>ÔÞaæM	¨
©HX®Î%)IIO%*DjôE”råÓcŽ…£X^kŒtdÂÎ" Àê%Z­m	Ó	™»he„W9à@[»ƒ-w¸èî²ªî žå·t3ƒ÷“«Ïq_Z3×æ 0ØÍ	íýÏ,/×‰{}ò;3PFTW¾å  Ÿë‰SwÚSYx2;²Æ¦óæôþ0Åbnö]Q" SÏôõž§òš	É
ö?_Å{Óë“’¹?ã|"¬jÄø�" Q ½ ò EÃÿ`ªÌ‡	:K½ê—=›:ÌUªÝ~/h¹l" ] e (œœ	8	C	
¼
ÿ
�·tõ;]Pn¶:Ju{Ÿ7fâ8–™\� Ý®ÚÚÍ;	8
š
£ @Uþ�åùf—*ÓŒ·šNÞ+ z†¢õ$\	î	N
{
“
@ð> p…‹åcÜg(OÓÚtû)s<7— �hZdò	°Qq$`ká-ô  çs"Ð	dÜGPG#àï�ÊÂEV> f´þ\§Àõþb# îxËP"L
v
‰
‘
1½Úm0»O$4>*´…±ÊáS ü·�ö! y :™D©‚	‹
Ü
I¯Jk'<FQ&s¥‚�˜Y�©0åo¹Ã# è èð'^þxÂÇ%•	N	©
ÏÙõ•ÙYd§3¤°úE:¢ëïÑ( >AjÌHf´ÍÕßâRçx
s¿ÂÎDÊý&J+æ6IÔ¤†_‡^ÀØ®¶e) Î D¹¾?úb
ß
ªY_
*o~P»&E_’›Úã/Èíly³Ju�Ïøþ<*  X àÁâë›[h®	n	Ô	K¼öŒâþf…ÞXËß	*"‘®9¹odn«ï ’Æni¡±á¼‰„¶ŸïÀL–ê ‹ L³ÔQ^ð
¿‹§ÇáCx�¢ªé2L’"q¦³* ±&Vn88¤	kš/:BÆŠÍÛ?|:(A\uÉnq„!|À™.€†¶
žMc àG˜EUuž�
d'{¿O¬°$X±‰$…ŽÉ„T` Ÿæ¸+
g"ŸâýJÃ3I…°Ó  ,mÐ<ð`&_{»Øû ª ªqtÿÞ
4„žÜø”r<D[4P� VPGç	… ËXøo©ÙÈ	!
þ±ônÐ0©Ø~ÀQGæ Ç ”1"\­¦¶pJò  - } ÊqñîC8ÑÝþãûžŠñ|ÿhó�4/X¿¤ » ð Cý¼«Î	ÈûN‚I-X<NUfä  + { §ô-L¼üAÁÙíeÇô1¬57ýBŒyÅ^ G ?�>	Þy¤Ðïì§õúÄDÍ*Ô3Ç%/   B»Ñd"Ø	„	 
{ˆTˆ¾ú,{aŽÐêšöS[cot7‚˜ÅÖ÷$×y—QÆR6 — £ ± Ù 6X<ì…­FeŠx{ÛTZz‚=Ã	3<³Ç)2>HS�k‡öçÿ	Gil–Æ«)^ç{2 ü[ã N�Ÿ¨½äó8†sÈ-<¸Ý	Ê
÷’r�–¢ÍÞêò�º/Ôì	”ºÆëSdw@#‚$ # rqÁÝõ4OöWú)Ä	V	F
`Ôœ¦ît—T´@€š;F¤ÏÅ…" h‰¼¥Õ&;�8—ÌJ@	w	ë	W
µ
€BäÇå} {ñÖÓ2/ 0TÐðATØ €›P	i	è	0
@{¦ñŸÆç|Äîù÷©Ý“àgj8#­¸¼kîù$  0ê¾Wa	MoÒ�–²3
]
«
`Lë˜›@;ü4V4ºuz! )IŠ¬�Í,	ä
IŠ÷Z°øÀí
5œØã-«ž+5¸d$ R ¾ Ü ó FÄ «·”úhÑ
7««É8¾Xiö> ÍÞƒ°imˆ § 6ñ|ˆ	;ûÉQKÏª2GÝ,x0îr m©ò�I�e	ë
 žÑµýX^7Q·KvÐ ‹•ã�Ž f m ‚ Ñ )FD	
ö—w™|­¼<ö€]œ' 3 ^ µ ê _÷A´	â	½
¸0/ÒLÛ�!è#8g9š{Ë# Ž�Á·\É	9	u]°¹-<[¤©éoüSü;(8qíD—ü Þ–<	
iŸà¿6¤ÛÚ´VÔT�•OJ µÓÛéZËøz#	Û	Oÿž¦¨æ²+~É �¯Éë`ÍÄ?žÛ%	ö	›
$¥ÿúg˜an¼ßñâ òï	#Ô'Î¶	9
69ç$TYA˜fÊ¸›ê	Ý? š [{–Â5V}�ÓÙ'3]{‡ÛDÏäí/ A…]	™	®	À	ø	þ	O
|
A]Ð&�ê…©ûJÕÝh)œ»Ëq cpt$, ž )l+”IfÏ0HŒö+
”
§Ä™·Q]Œæd®c³Ëi ÞuüE=ñàT' Ph±A­%Êâé	ï	×<�ÞÇqx¢ñ8uP�ˆ‰¦Ø*È:  �‡íDJb‰™´ƒ£ê{ÿ'	S	t	C
Å
Š~ŠÖñ36?“¡†_·Kt‹BOü qƒ”&ÔÛ€Úó8?˜ @ ƒÆì~•	§	¹	±µ%ae¾»
 ÿÎ
•R"7aÔà¯â  <¢i±½[½ÝÚj}¢bÀ>‘<DÌ�rX8.õ �‘¨e‚ó	<
�
á
ü‡¤—³¹l\=o „Øt‘Œ	?
Ä‚‘ðÑ.èD}ËE»Òk?¡ö]B ‡ s’šÒ@Æ²	&
d
eàFš,YlÿÁ›+ å |$T¢
u�–´ÝFPVÌrL -BbwËá¨º�cÜ®Ç`gÂàŠÿg%  èœ¥#ÓØÑ	§
¨ÿ$(HQWH$)Òo�ÃW]¶ìµd°¨öc ä¶×l	2˜Ùw1‚öºò+Öamv|Sä- Ü­_Îó©Ëô	†	7
È
s^¼?µ9œäøe–š9ËÒâT{‹!™á.•¸[Ž# wyYô#K
M
z
’
?Û=F¯Pî„Šb'_U„Ùý[¶a1 ï9@CËGewÆÌá$Q	�	w
Š
r¾ÁC^n}šâ&;PÇ%5Hì¦x†²ùI¡ên­¸÷; áUš7g	J9°>Ê'tŠ¦)ƒÆ{�˜µž1K	�¿pb ßFDþ*
Œ
Ý
+&lz�NüIï;OŽÈºSÒú„ »npª¬ð°Hm¨WñM7 z – ¢ ° W;A¦EdŒ×ƒ	z‡,Ky�»@ù(1=GR€+j`�Ïéhk™ Zü—ª#‹æÓxÅ2Ä$3 " gpÀâ3:Nœÿ7SŽ×7–,;·O	´

q•žÌÝæA–ø¨ßêcäz£·»ðÒ1 ¦ Û /é(½«ùÐ+	\
ª
7_~‰öš?JÎ41ûFw3í# l ´ Ð é ¨ö@ñÈHŒ	á	ê
Ð.–¯,KWÚZ�6R;pì7”( ñŒîÈè_
÷yÃ&>"	
#58hæ#SX¾5ÚÙ—eÉ¥±`m”}áÜ9 ™ Z4Ok†IUgˆŒ“&°Îãé*¬záèþs	­	¿	
Ï;}Ýé2„’Æ¶¡­7JŠAN‡Êpˆ“¥DÙß> ;€þ¼ë”	¸	;
a=!6´Ó®º( r~?S×‹	%
t•ÃE�Ëþ#'VqK(,aÊçCn­µ+ë_Á¯f ?BÍ¨µÖàóy
>À]E]|�ƒ‰Õ¥^`{é·& • ¯ VEº@mý6c‹Ö*«ï†+€º?G0É‰§îÿNJLaÑù3 k ¥ ³ Ï fõ?‹¼¿áMÖ6=ø+¶!	*	
"	"-RW^p½ˆ”�Üå+@JVŽ5IÈÍy“v“àì* :3Ný‡%¯èò)«àý¬	¾	
\`\p‘Å'`µÉ 5¬oz’´ =4 ­ ® 89ô>Mûü5;<ö÷Š !Z[!,QV[\]¼F‡“œÛä4UÌmnKx‘’Ðÿ  5À  ›GACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GCACNNNNNNGTTSAACNNNNNNGTGC,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNNNNTTYG,CRAANNNNNNGTC,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,TCGGTC,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,TTSAA,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GCTCC,GGAGC,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,CCDG,CHGG,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                       +                                                                                                                                                                                                                                                                                                                            6                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      	                                                                                  	                                                 "                            *                                                                                   
         6                                           	                                       &                                                                                           $   -      	                           B   -                     	   
                                                                  	   
   	                        7   &      +   %      (   3         ¯   ^      "   ‹   �         '      o                    +                                                                                                                                                    6                                                                                                                                                                                                                                                                                      	                              	                 "          *                               
   6               	             &                                 $ -  	         B -       	 
                      	 
 	        7 &  + %  ( 3   ¯ ^  " ‹ �   '  o   ‚Û  „K  „q  „Ù  ŠU  ‘  šÉÏ›5È#È¤k p‡ÿ%&nŽ×µÈû)*SöŠ	ð#†Ë'2„	,^_~ÅRm�¨1ßñ—®G¥íÕW†�j2ùhŸŠPd	Ü!” U¾Þ”ÃQ‚
|õõÅæuÕ<Œ¯÷ ” .U²ÊCM\›³¼ÊÚö¥7 	|€Ü8D¿Œ¥ÏÑû4¯÷*ywËâmsè;HÉõIŒþ:¾N
Ä»	ÃÆ�2G‘2PG2G22ã©òë
7DãJŒ•ÝêŠ‚ÖÍµÄ_´
üý
8âãü)¼	ný
èÑÚìøËäÍ*HGÍ
*Ç
šTãµ:‰Ëgú	�12ç‡úo	»	&ŽÚ
ãõhàå¹Y²óá¾		pþI�þg	�ö
$á±¹ î AûÆùâñ	RYå¢ê(y‰MÛŠ*ÛŠ}…¨Ïƒ	é™®Ãk5¡	Š“-¢48(Ö]x.Ðç–
K]f)”0Œ³Þœ¥ö
¹ î AûÆù…E”dâÒ* Ï? ötáÈÑ	ó±	’ç		çEl	É2‡'F £jé$÷ë¸	´Å}Jj2‡'	¢L©	ç4ÖÙ
tá2‡'•t¬ï–V×Ö|ä…Æ+æ!Ï	Od	´ü¸Vƒ —ç.„÷	If@y±íƒS	t	C
Ç·Ø—= }	…QÃa�óÛg‚/�Šï1239‡ˆo	Ù
'¶3h}˜à…¨ÏívŸrÀÙ]{Û]	»¦¡?_9T¸»¸Qòlv(�’Z
¤´¨ñ3~áâŒá%Ž65ë+;¶¬	¸	¾	¿	ª
h°Ð,	
pq”ÜWz´É)6Êo ¯¥�0oh‚08T8=Åz—œ-ÀÞé‚Àã¡@Ëw
¾(Ö�å˜	¨~ÿù¢(x »P`¨ñÐW6 0táJjÈÑ2‡'	•¢t¬L©ó±ï	’çÿ
Ÿ�ÏR¨ñ~ë¸	ª
ÐW´6FUau¯
ãµ” UÁÅûVZ…|2¨n}±Õd	r	2
|…Ø18>vŒ=¡´éüÔ¯ñ÷@Dz—þˆÞ3º_¨ñh°Ð,W6d	´üÏ’Za¦Ù
j�â1'±P[±½½Îó ;�u°¤ü¤Ëv	V
Õ�ë`%	úñÉ,ÌÄ×‹l‡:D'<FQ©åtá-)”Ù]{Û0Œ]	³»Þœ¥¦¡öTè	Ÿçg8êŠ3Ûç–
¶þ). °YåÕ. Y°:�	ñ	¯
	¡ØéRY	ñçå D`jÀêžt\	Ó	{
ÿ
1@•ê—ÓÜ/g“í0U¸> UŸ¢�îø·úˆ* Ü
�EgÒI8=z—AØ€P	‡,¦î#ÅCyMÇ˜íƒS	t	C
·Ø€P	¦îYåÒ_9?T¸p
nÏ›9Q‚w²iŠ½*|Ã¥çB¡çåÙ
jâú1'±P±½ëø§Ú
€¢\¾ŽÏüµ
¢Tku¡™ Z4âUŒÿ&Ž7Îã,;·­	¿	Ïé„
q•ÌÝÊêcpíˆ
�
ÙŒ¸`Qòlv×	§(î� /ïC@˜³ÿ‚R	h	B
‰‰Õ5z¥ð^ÃísöÜp‚%fi7í “ ThÅåû
�™üPæï239è)‡ˆû	p	‘	¼		
'(í v4n�¬ŠvÅÖ´áš6g	JÉÊ‰)�Ja¬7:®
ñ
hš&Í8
@·šhÅ
�üPï‘	 ŠÖ´/ï@ÿh	z¥ðÃíöÜfi7í C˜³‚R	B
‰‰Õ5^sp‚%È¯,ZRpìsg£�¾jÅ{ µl /ïC@˜°³ÿm‚¥7R	h	£	B
‰y‰Õ.5Axz‰¥ÌÚð*^iÃÈímps_¿èöjÜp‚…û–%fi7ÒíL1#™ Z4âUŒáÿ&Ž7šÎã6g,;·	­	¿	ÏJé„
q•ÌÝÉÊ‰)�ÊêcpJa\¸ ¨èûû'Cû¯z`
fe= •ØC.Ÿ„÷	ý	\%úIbo#g:œ7–´
AäzðÒ1y¢ô½Öž·\]-8íÎóôÈ
^â{!+IfÏH
Œ=Tá x �’ú	L÷#’½Þ
	‘ÙŠ K]Ô%@IoÉï
¾ tàV©ðÆÿÎóÿ+ôIfÏH
È
^Œâ{!=T›¥Õ&8Ìw	W
µ
}{Ö�ë`Í?ž%	ö	$¥úganñEbE”5wMe• ¯ V@c‹Ö†+€º?0ÿõýÝ!­8Ú«™Éu¿
Ž
íeÖìkñ%a†*k¶BG
”qÿ«‚Üø-DX4NUäçôõõ	‹
“
Ü
_hk‹àåc»ƒ?�îtû¹Ä<×þ#'V(nµë¯+–*Ž¹â Õ
£³kÁÂ&Fd#	€	qB™áÆGëwø m¬:‚/í/w¡ÂÇàjÂÄ	Í~ Õ 2§Ù¤;XÌéõÿ1é4sçM‡ Üu¯Æ+
ãµY‘ç"Ð	GPG#ÂV´§õb™
Ž
eÖBÚ«Éuì%kG
§Ù¤;Ìõÿ1M ¿íkña†*¶”°m¥7£	y.Ax‰ÌÚ*iÈmp_¿èj…û–ÒL1#�¥Õë&`8Í?žÌ%	w	ö	W
µ
$¥úgan}{Öñ­²t(Ð�d ¶ôm6e‘ Ké©¯ + { §ô-L¼üAÁÙíeÇô1¬57ýBŒyÅ^z – ¢ ° W;A¦EdŒ×ƒ	z‡,Ky�»@ù(1=GR€+j`�Ïéhk™ Zü—ª#‹æÓxÅ2Ä$²ÓP°Åm7£	mõ.Aý‰ÌÚÝÈmpˆ¿!­8B…Œ¡‘!¥L• 3j‹¾[Ü#<‹Â
·+uÀÖâñ{1Gy£Ù�€ÄQ	j	—	5
AÂ§NO�ÅÏï¹ÞciÞ”vþÿl«m ÿ¬!~	ó½£ÂÏØî~†Æëõù«õ6Rs�Ä(ÖCÌ)zÆ]@ ƒÆì~•	§	¹	±µ%ae¾»
øX‡b§6	Ë	Ú
ý
kžãèû2€ÑÚ(¢²Q\d²¾'|Ž¼¾Ïóìôü  “ Tæûš5õæ39é)9ˆû	q	¼	ß		
(í0Cw5n�­;x~²)×^y/Ýèú¬vÆÑáUš7g	J9°>Ê'tŠ¦)ƒÆ{�˜µž1K	�¿pbm©ò�I�e	ë
 žÑµýX^7Q·KvÐ ‹•ã�Ž  i “ œ Tu}˜ÀÄÖâ1]„æñû18S{š15BG[y—£²Ùõ4FW�Ñæ
39¦é)9?€ˆ´Äû
			Q	j	q	—	¥	°	¼	ß		
5
Ì
(²íA–›ÂÔ0;Cw“5nu|�§­@N­;O˜à[x~�¦²¸ÅÏ):B]vÊÓ×ïar…Äðú^y}¢¹ÉšÞci³ÈÞ/�”Ýèúvþk¬·âÿjvŸ¹½Æbl«Ñ/m}' f m o q ‚ É Ñ )+bmu©jl²ò�\I�¾ÞFÛD	e	
f
ë
÷
 k~ž¯ÈàÑÁö—%¬µôýXpÕE^w7Q™s·âKSv|­¼ÐYŠ èêì<_‹•ãéöI€]�œ'Žº Æ ï B“ü÷![ 
ýÇú�7¥ÐÜúµŽ.£ãúˆ£îµ»„²T	g	u	D

®·öÿr¾¸guÛ!
2�ÛœôèŒ" ™ Zg4Okp†Àâ3:INUgˆŒ“œáÿ&7SŽ×7Uš°Îãé*7g–¬,;z·áèþ	O	s	­	¿	
´
Ï;J}Ýé29„°
q’Æ>¶•žÌÝæA–Ê'tŠ¡¦­)7JƒŠÆøA{N�˜¨‡µÊßêcpˆ“ž¥1Kä	Dz�£·»¿ÙðpbÒß1>š [{–Âü5[ãV}�ÓÙá '3N]{‡�Ÿ¨½Ûäó8DU†šÏäí/7gs È-<A…¸	]	™	®	À	Ý	ø	þ	O
|
Ê
A]Ð÷&J�’ê9…°r�©>û–¢ÍÞêÊò'Jt�Š¦ºÕ)/ƒÆÔÝì	h{”)�˜œ»µËºÆëSdqž 1Kcpw	t�¿@p$b#‚S ¢è¸û—
L¬^im¿c�¡ìÈúùg‰?BÍ¨µÖàóy
>À]E]|�ƒ‰Õ¥^`{é·ddwÃ-úY~ÀÞéìv‚æÀóù%ã‘v|¡¤°ø8À%?B†gMG ¤ÍÓä	f�ÔãEVakê%‘ÅÊØøŒ,jº Æ ï Bq“üeuÀÖâ÷
!ñ{’§û1Gy£Ùí9>�Ö[y€ÄôQ	j	Š	“	—	·	 
5
:
­
=ý:AÂÇèú"�§7N€¥ÐÜOÎ�ÅÏ  ïúB‰µ¹MyÞ]ciÞ”Cv¤Üïþ‡êÿŽ¹.l«£ÞãNmžå·t3ƒ÷“«Ïq_Z3×æ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  )E<?xml version="1.0"?><Features nextValidID="20"><Feature recentID="0" name="Kifc1-m" directionality="1" translationMW="74155.34" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2852" maxFusedRunOn="2852"><Segment range="756-2777" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MDVQAQRPPLLEVKRNVELKAALVKSSSRVPLSASRLKRGPDQMEDALEPAKKRTRVMGAVTKVDTSRPRGPLLSTVSQTQGHTAAQKGPKKTGPRGCSAIGTVLRSQKPVPAAPAQKPGTSTAPVVVGKRAGKRPAWDLKGQLCDLNEELKRYREKTQTLELENRGLREQLREVQEQATTLGTERNTLEGELASVRSRAEQDQQRLETLSARVLELEECLGTRERLLQELQGERLQLQEERSTLSTQLEEQERRFQATEAALSSSQEEVVCLRQKTEAQVTLLAEQGDRLYGLEMERRRLHNQLQELKGNIRVFCRVRPVLEGESTPSPGFLVFPPGPAGPSDPPTGLSLSRSDDRRSTLTGAPAPTVRHDFSFDRVFPPGSKQEEVFEEIAMLVQSALDGYPVCIFAYGQTGSGKTFTMEGGPRGDPQLEGLIPRAMRHLFSVAQEMSGQGWTYSFVASYVEIYNETVRDLLATGPRKGQGGECEIRRASPGSEELTVTNARYVPVSCEKEVEALLHLAHQNRAVAHTAQNKRSSRSHSVFQLQISGEHAARGLQCGAPLNLVDLAGSERLDPGLHLGPGERDRLRETQAINSSLSTLGLVIMALSNKESHVPYRNSKLTYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKVNQCVIGTAQANKK"/></Q></Feature><Feature recentID="1" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="750-759" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5779-5795" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5755-5771" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5848-5869" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="5803-5809" color="#ffffff" type="standard"/><Segment range="5810-5827" color="#ffffff" type="standard"/><Segment name="-35" range="5828-5833" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="HSV TK poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3527-3575" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;herpes simplex virus thymidine kinase polyadenylation signal&amp;nbsp;&lt;a href=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot; title=&quot;http://www.ncbi.nlm.nih.gov/pubmed/3018551&quot;&gt;(Cole and Stacy, 1985)&lt;/a&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="2849" consecutiveTranslationNumbering="1" maxRunOn="2852" maxFusedRunOn="2852" detectionMode="exactProteinMatch"><Segment range="2784-2849" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="DYKDHDGDYKDHDIDYKDDDDK"/></Q></Feature><Feature recentID="8" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7777-7881" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5585-5706" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4399-4534" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="430-633" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4219-4548" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="50-429" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3777-4205" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6157-6745" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="WPRE" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2873-3461" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;woodchuck hepatitis virus&amp;nbsp;posttranscriptional regulatory element&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4615-5409" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="18" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7707" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6916-7707" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7708-7776" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="19" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="678-696" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ¨<Notes>
<UUID>6ed48287-2a69-41c6-bb14-0cb95ec2fffb</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCMV-Kifc1(mouse)-3Ã—FLAG-Neo</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="5:0:4">2019.1.23</Created>
<LastModified UTC="17:40:53">2025.9.20</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                              ©<StrandColors><TopStrand><ColorRange range="0..8096" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..8096" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
